(Edit: Hey! Thanks for the feature! If I'd have thought that would happen I'd have at least kicked that subwoofer back into the corner. I feel like I'm having company over and I've neglected to even pick up the dirty socks)
I was using a build with a Strix X99 motherboard and an i7-6800k. Long story short, the processor died. I believe the motherboard did the killing. The Asus rep who posts here says it is user error. Lots of users seem to be having this error. But that is another story for another day. I've added a few pics of the setup while troubleshooting.
I switched to an MSI Pro Gaming Carbon. It seems somewhat less than the Asus board. You get less things. It hasn't killed a processor yet. But lets face it. You only buy this board for the RGB back-lit dragon. I also upgraded the processor to an i7-6850k and added an additional 32GB of RAM. Do I need 64GB of RAM? Nope.
The biggest upgrade might be the switch to hard tubing for the water loop. I thought it was going to be a fun project for a Saturday afternoon. Not so much. It was pretty frustrating. Eventually I ended up with something I could live with. Mostly, I just looked at the GTX 1080s sitting on the kitchen counter and wanted to get back to using them. Rather than repeatedly burning myself on a heatgun and re-doing the same tubing bends over and over.
The Define S claims to fit a 420mm rad in the top. While the radiator does technically fit, fitting fans and running tubing was beyond my patience and ability. I'm satisfied with the case though. It replaces the monolithic Corsair 760t I had been using.
The fittings, tubing and reservoir are from Primochill. They all worked great. I had some issues with the reservoir/pump but primochill offered some advice. So no problems there. It's all working great. The pump is from Swiftech.
Excuse the poor desktop cable management. I've not managed it yet. Some people care about how their desk looks. I'd rather spend my time killing more drowners.
I've added a gratuitous photo of the dog. He needed to know what the heat gun noise was.